The Gut Microbiome as a Major Regulator of the Gut-Skin Axis

Frontiers in Microbiology

Iman Salem¹  Nancy Isham¹  Amy Ramser²  Mahmoud A. Ghannoum² 

[1] Center for Medical Mycology, Department of Dermatology, Case Western Reserve University, Cleveland, OH, United States;Dermatology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States;

关键词: gut microbiome;    skin homeostasis;    acne vulgaris;    atopic dermatitis;    psoriasis;    probiotics;   

DOI  :  10.3389/fmicb.2018.01459

来源: DOAJ

【 摘 要 】

The adult intestine hosts a myriad of diverse bacterial species that reside mostly in the lower gut maintaining a symbiosis with the human habitat. In the current review, we describe the neoteric advancement in our comprehension of how the gut microbiota communicates with the skin as one of the main regulators in the gut-skin axis. We attempted to explore how this potential link affects skin differentiation and keratinization, its influence on modulating the cutaneous immune response in various diseases, and finally how to take advantage of this communication in the control of different skin conditions.

【 授权许可】

Unknown