Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS)

International Journal of Environmental Research and Public Health

Margherita Bianca¹  Daniela Caccamo²  Giovanni Damiani³  Paolo Daniele Maria Pigatto³  Marco Alessandrini⁴  Alberto Migliore⁵  Alba Piroli⁶  Andrea Mazzatenta⁷  Alessandro Micarelli⁸  Andrea Cormano⁹  Gianpaolo Guzzi^1,10  Ottaviano Tapparo^1,11 

[1] ;Department of Biomedical Sciences, Dental Sciences, & Morpho-Functional Imaging, Polyclinic Hospital University, 98124 Messina, Italy;Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy;Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy;Department of Internal Medicine, Unit of Rheumatology, San Pietro Fatebenefratelli Hospital, 00189 Rome, Italy;Department of MeSVA, University of L’Aquila, 67100 L’Aquila, Italy;Department of Neuroscience, Imaging and Clinical Science, ‘G. d’Annunzio’ University of Chieti-Pescara, 66100 Chieti, Italy;Institute of Mountain Emergency Medicine, Eurac Research, 39100 Bolzano, Italy;International Society of Doctors for Environment, 82100 Benevento, Italy;Italian Association for Metals and Biocompatibility Research—A.I.R.M.E.B., 20122 Milan, Italy;Natrail Tagesklinik, 81925 Munchen, Germany;

关键词: multiple chemical sensitivity (MCS);    chemical intolerance;    threshold limit value;    environmental exposure;    neurogenic inflammation;   

DOI  :  10.3390/ijerph182111294

来源: DOAJ

【 摘 要 】

Multiple chemical sensitivity (MCS) is a multisystem, recurrent, environmental disorder that flares in response to different exposures (i.e., pesticides, solvents, toxic metals and molds) under the threshold limit value (TLV) calculated for age and gender in the general population. MCS is a syndrome characterized by cutaneous, allergic, gastrointestinal, rheumatological, endocrinological, cardiological and neurological signs and symptoms. We performed a systematic review of the literature to summarize the current clinical and therapeutic evidence and then oriented an eDelphi consensus. Four main research domains were identified (diagnosis, treatment, hospitalization and emergency) and discussed by 10 experts and an MCS patient. Thus, the first Italian MCS consensus had the double aim: (a) to improve MCS knowledge among healthcare workers and patients by standardizing the clinical and therapeutic management to MCS patients; and (b) to improve and shed light on MCS misconceptions not supported by evidence-based medicine (EBM).

【 授权许可】

Unknown