GI Symptoms in Infants Are a Potential Target for Fermented Infant Milk Formulae: A Review

Nutrients

Olivier Goulet¹  Amelie Berton²  Bert J. M. van de Heijning²  Hetty Bouritius² 

[1] Department of Pediatric Gastroenterology-Hepatology and Nutrition, Necker Children's Hospital,University of Paris, 75015 Paris, France;Nutricia Research, Early Life Nutrition, P.O. Box 80141, 3508 TC Utrecht, The Netherlands;

关键词: infant milk formula;    fermentation;    GI function;    GI symptoms;   

DOI  :  10.3390/nu6093942

来源: DOAJ

【 摘 要 】

Besides pre- and pro-biotic-containing infant formulae, fermented infant formulae are commonly used to relieve or prevent symptoms of gastrointestinal (GI) discomfort in young infants. During the fermentation process in cow’s milk-based formulae, the beneficial bacteria modulate the product by forming several beneficial compounds, which contribute to the alleviation of the symptoms observed. This review summarizes the clinical evidence on the impact of fermented infant formulae on common pediatric GI-symptoms. The potential mechanisms involved are discussed: i.e., the lactose and protein (in-) digestibility, effects on gastric emptying and gut transit and modulation of the colonic microbiota. Although initial evidence indicates a beneficial effect of fermented formulae on GI discomfort in newborns, validation and confirmation of the clinical proof obtained so far is warranted, as well as further research to (more fully) understand the mode of action.

【 授权许可】

Unknown