Diagnostic Pathology | |
Expression of MK-1 and RegⅣ and its clinicopathological significances in the benign and malignant lesions of gallbladder | |
关键词: gallbladder neoplasms; gallbladder polyp; chronic cholecystitis; tumor-associated antigen; MK-1; regenerating gene Ⅳ; immunohistochemistry; | |
DOI : 10.1186/1746-1596-6-100 | |
来源: DOAJ |
【 摘 要 】
Abstract
Background
To study the expression of MK-1 and RegⅣ and to detect their pathological significances in benign and malignant lesions of gallbladder.
Methods
The expression of MK-1 and RegⅣ was detected by immunohistochemical method in paraffin-embedded sections of surgical resected specimens from gallbladder adenocarcinoma (n = 108), peritumoral tissues (n = 46), adenomatous polyp (n = 15), and chronic cholecystitis (n = 35).
Results
The positive rate of MK-1 or RegⅣ expression was significantly higher in gallbladder adenocarcinoma than that in peritumoral tissues (χ2MK-1 = 18.76,
Conclusions
The expression of MK-1 and/or RegⅣ might be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma.
【 授权许可】
Unknown