Mapping functional connectivity of bursting neuronal networks

Applied Network Science

Kelly D. O’Connor¹  Nick Bolle¹  Tuan D. Nguyen¹  Krishna Sheth¹ 

[1] The College of New Jersey, Department of Physics;

关键词: Calcium imaging;    Laser scanning photostimulation;    Neuronal network;    Network bursting;   

DOI  :  10.1007/s41109-017-0037-0

来源: DOAJ

【 摘 要 】

Abstract Using single-cell laser scanning photostimulation (LSPS) combined with broad-field calcium imaging, we measured the functional connectivity of neuronal cultures before and after the developmental appearance of network bursting. From these data, network properties were determined for these relatively large neuronal networks. Based on these properties, we found that although ‘small-world’ network behavior existed throughout this time period, only average node degree and global efficiency correlate with the development of network bursting while clustering and local efficiency remained relatively constant.

【 授权许可】

Unknown