N-halamine surface coating for mitigation of biofilm and microbial contamination in water systems for space travel

Biofilm

Alicia Taylor¹  T.-S. Huang²  R.M. Broughton³  Buket Demir³  S.D. Worley⁴  M.J. Bozack⁵ 

[1] Halomine, Inc., Ithaca, NY, 14850, USA;Center for Polymers and Advanced Composites, Department of Mechanical Engineering, Auburn University, Auburn, AL, 36849, USA;Department of Chemistry and Biochemistry, Auburn University, Auburn, AL, 36849, USA;Department of Physics, Auburn University, Auburn, AL, 36849, USA;Department of Poultry Science, Auburn University, Auburn, AL, 36849, USA;

关键词: N-Halamine;    Stainless steel;    Inconel™;    Antimicrobial coating;    Disinfection;    Biofilm prevention;   

DOI  :  

来源: DOAJ

【 摘 要 】

A copolymer termed HASL produced from monomeric units of 2-acrylamido-2-methyl-1-(5-methylhydantoinyl)propane (HA) and of 3-(trimethoxysilyl)propyl methacrylate (SL) has been coated onto stainless steel and Inconel™ substrates, which upon halogenation with either aqueous oxidative chlorine or bromine, became antimicrobial. It has been demonstrated that the halogenated stainless steel and Inconel™ substrates were effective in producing 6 to 7 log inactivations of Staphylococcus aureus and Escherichia coli O157:H7 within about 10 min, and in prevention of Pseudomonas aeruginosa biofilm formation over a period of at least 72 h on the stainless steel substrates. Upon loss of halogen, the HASL coating could be re-charged with aqueous halogen. The HASL coating was easily applied to the substrates via a simple dip-coating method and was reasonably stable to contact with water. Both chlorinated substrates could be loaded with at least 6 × 1016 oxidative Cl atoms per cm2 and maintained a loading of greater than 1 × 1016 chlorine atoms per cm2 for a period of 3–7 days while agitated in aqueous solution. After loss of chlorine to a level below 1 × 1016 atoms per cm2, the substrates could be recharged to the 6 × 1016 Cl atoms per cm2 level for at least 5 times over a 28 day period. The new antimicrobial coating technology has potential for use in a variety of important applications, particularly for water treatment and storage on spacecraft.

【 授权许可】

Unknown