Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study

Nutrients

Youxin Wang¹  Xiaoyu Zhang²  Shanshan Chen³  Xiuyu Pang³  Xizhu Xu³  Guanhua Liu³  Fang Dong³  Weijia Xing³  Zihong Song³  Ruyi Cong³  Yizhi Liu³ 

[1] Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, China;Department of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, China;School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai’an 271000, China;

关键词: gout;    uric acid;    adiponectin;    soluble leptin receptors;    mendelian randomization;   

DOI  :  10.3390/nu14051091

来源: DOAJ

【 摘 要 】

Previous observational studies have highlighted associations between adipokines and hyperuricemia, as well as gout, but the causality and direction of these associations are not clear. Therefore, we attempted to assess whether there are causal effects of specific adipokines (such as adiponectin (ADP) and soluble leptin receptors (sOB-R)) on uric acid (UA) or gout in a two-sample Mendelian randomization (MR) analysis, based on summary statistics from large genome-wide association studies. The inverse-variance weighted (IVW) method was performed as the primary analysis. Sensitivity analyses (including MR-Egger regression, weighted median, penalized weighted median, and MR pleiotropy residual sum and outlier methods) were also performed, to ensure reliable results. In the IVW models, no causal effect was found for sOB-R (odds ratios (OR), 1.002; 95% confidence intervals (CI), 0.999–1.004; p = 0.274) on UA, or ADP (OR, 1.198; 95% CI, 0.865–1.659; p = 0.277) or sOB-R (OR, 0.988; 95% CI, 0.940–1.037; p = 0.616) on gout. The results were confirmed in sensitivity analyses. There was no notable directional pleiotropy or heterogeneity. This study suggests that these specific adipokines may not play causal roles in UA or gout development.

【 授权许可】

Unknown