Tumor-Associated Neutrophils in Cancer: Going Pro

Cancers

Sugandha Saxena¹  Lingyun Wu¹  RakeshK. Singh¹  Mohammad Awaji¹ 

[1] Department of Pathology and Microbiology, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, NE 68198-5900, USA;

关键词: neutrophils;    cancer metastasis;    neutrophil extracellular traps;    neutrophil polarization;   

DOI  :  10.3390/cancers11040564

来源: DOAJ

【 摘 要 】

The progression of cancer is not only about the tumor cell itself, but also about other involved players including cancer cell recruited immune cells, their released pro-inflammatory factors, and the extracellular matrix. These players constitute the tumor microenvironment and play vital roles in the cancer progression. Neutrophils—the most abundant white blood cells in the circulation system—constitute a significant part of the tumor microenvironment. Neutrophils play major roles linking inflammation and cancer and are actively involved in progression and metastasis. Additionally, recent data suggest that neutrophils could be considered one of the emerging targets for multiple cancer types. This review summarizes the most recent updates regarding neutrophil recruitments and functions in the tumor microenvironment as well as potential development of neutrophils-targeted putative therapeutic strategies.

【 授权许可】

Unknown