Non-viral gene delivery systems for tissue repair and regeneration

Journal of Translational Medicine

Chunmao Han¹  Ronghua Jin¹  Chuangang You¹  Xingang Wang¹  Jon Kee Ho¹  Liping Zhang¹  Haojiao Chen¹  Tingting Weng¹  Pan Wu¹ 

[1] Department of Burns & Wound Care Center, Second Affiliated Hospital of Medical College, Zhejiang University;

关键词: Non-viral vector;    Tissue engineering;    Gene therapy;   

DOI  :  10.1186/s12967-018-1402-1

来源: DOAJ

【 摘 要 】

Abstract Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery. The ideal treatment for such tissue loss is autografting, but donor sites are often limited. Tissue engineering (TE) is an inspiring alternative for tissue repair and regeneration (TRR). One of the current state-of-the-art methods for TRR is gene therapy. Non-viral gene delivery systems (nVGDS) have great potential for TE and have several advantages over viral delivery including lower immunogenicity and toxicity, better cell specificity, better modifiability, and higher productivity. However, there is no ideal nVGDS for TRR, hence, there is widespread research to improve their properties. This review introduces the basic principles and key aspects of commonly-used nVGDSs. We focus on recent advances in their applications, current challenges, and future directions.

【 授权许可】

Unknown