Plasma Soluble Human Elastin Fragments as an Intra‐Aneurysmal Localized Biomarker for Ruptured Intracranial Aneurysm

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Pascal Jabbour¹  Santiago Ortega‐Gutierrez²  Edgar A. Samaniego²  Daizo Ishii³  Joseph Hudson⁴  Nahom Teferi⁴  David M. Hasan⁴  Daichi Nakagawa⁴  Mario Zanaty⁴  Lauren Allan⁵ 

[1] Department of Neurological Surgery Thomas Jefferson University Hospital Philadelphia PA;Department of Neurology, Neurosurgery and Radiology University of Iowa Hospitals and Clinics Iowa City IA;Department of Neurosurgery Hiroshima University Hiroshima Japan;Department of Neurosurgery University of Iowa Hospitals and Clinics Iowa City IA;Department of Surgery University of Iowa Hospitals and Clinics Iowa City IA;

关键词: biomarker;    elastin fragments;    ELISA;    intracranial aneurysm;    rupture;   

DOI  :  10.1161/JAHA.118.010051

来源: DOAJ

【 摘 要 】

Background Fragmentation of the tunica media is a hallmark of intracranial aneurysm formation, often leading to aneurysmal progression and subsequent rupture. The objective of this study is to determine the plasma level of elastin fragments in the lumen of ruptured versus unruptured human intracranial aneurysms. Methods and Results One hundred consecutive patients with/without ruptured saccular intracranial aneurysms undergoing endovascular coiling or stent‐assisted coiling were recruited. Blood samples were collected from the lumen of intracranial aneurysm using a microcatheter. The tip of the microcatheter was placed inside the aneurysm's sac in close proximity to the inner wall of the dome. Plasma levels of elastin fragments were measured using an ELISA‐based method. Mean plasma level of soluble human elastin fragments was significantly greater in ruptured aneurysms when compared with nonruptured aneurysms (102.0±15.5 versus 39.3±9.6 ng/mL; P<0.001). Mean plasma level of soluble human elastin fragments did not have significant correlation with age, sex, size, or aneurysm location. Conclusions The present study revealed that a significantly higher concentration of soluble human elastin fragments in the lumen of ruptured intracranial aneurysms when compared with nonruptured ones.

【 授权许可】

Unknown