Spotlight on botulinum toxin and its potential in the treatment of stroke-related spasticity

Drug Design, Development and Therapy

关键词: post-stroke spasticity;    botulinum toxin;    abobotulinumtoxinA;    onabotulinumtoxinA;    incobotulinumtoxinA;    rimabotulinumtoxinB;   

DOI  :  

来源: DOAJ

【 摘 要 】

Michelle Kaku, David M SimpsonDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USAAbstract: Poststroke spasticity affects up to one-half of stroke patients and has debilitating effects, contributing to diminished activities of daily living, quality of life, pain, and functional impairments. Botulinum toxin (BoNT) is proven to be safe and effective in the treatment of focal poststroke spasticity. The aim of this review is to highlight BoNT and its potential in the treatment of upper and lower limb poststroke spasticity. We review evidence for the efficacy of BoNT type A and B formulations and address considerations of optimal injection technique, patient and caregiver satisfaction, and potential adverse effects of BoNT.Keywords: poststroke spasticity, botulinum toxin, onabotulinumtoxinA, incobotulinumtoxinA, rimabotulinumtoxinB 

【 授权许可】

Unknown