Trends in Meningococcal Disease in the United States Military, 1971–2010

Emerging Infectious Diseases

关键词: Neisseria meningitidis;    meningococcal disease;    infectious diseases epidemiology;    vaccines;    military personnel;    bacteria;   

DOI  :  10.3201/eid1809.120257

来源: DOAJ

【 摘 要 】

Meningococci have historically caused extensive illness among members of the United States military. Three successive meningococcal vaccine types were used from 1971 through 2010; overall disease incidence dropped by >90% during this period. During 2006–2010, disease incidence of 0.38 (cases per 100,000 person-years) among members of the US military was not significantly different from the incidence of 0.26 among the age-matched US general population. Of the 26 cases in the US military, 5 were fatal, 15 were vaccine failures (e.g., illness in a person who had been vaccinated), and 9 were caused by Neisseria meningitidis serogroup Y. Incidences among 17- to 19-year-old basic trainees and among US Marines were significantly higher than among comparison military populations (p<0.05). No apparent change in epidemiology of meningococcal disease was observed after replacement of quadrivalent polysaccharide vaccine with conjugate vaccine in 2007. The data demonstrate that vaccination with meningococcal vaccine is effective.

【 授权许可】

Unknown