Donnan Potential across the Outer Membrane of Gram-Negative Bacteria and Its Effect on the Permeability of Antibiotics

Antibiotics

Yinan Wei¹  Ankit Pandeya¹  Olaniyi Alegun¹  Jian Cui¹  Isoiza Ojo¹ 

[1] Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA;

关键词: Donnan potential;    Gram-negative bacteria;    antibiotics;    membrane permeability;    cellular accumulation;   

DOI  :  10.3390/antibiotics10060701

来源: DOAJ

【 摘 要 】

The cell envelope structure of Gram-negative bacteria is unique, composed of two lipid bilayer membranes and an aqueous periplasmic space sandwiched in between. The outer membrane constitutes an extra barrier to limit the exchange of molecules between the cells and the exterior environment. Donnan potential is a membrane potential across the outer membrane, resulted from the selective permeability of the membrane, which plays a pivotal role in the permeability of many antibiotics. In this review, we discussed factors that affect the intensity of the Donnan potential, including the osmotic strength and pH of the external media, the osmoregulated periplasmic glucans trapped in the periplasmic space, and the displacement of cell surface charges. The focus of our discussion is the impact of Donnan potential on the cellular permeability of selected antibiotics including fluoroquinolones, tetracyclines, β-lactams, and trimethoprim.

【 授权许可】

Unknown