Clinical Profile, Treatment and Predictors during the First COVID-19 Wave: A Population-Based Registry Analysis from Castile and Leon Hospitals

International Journal of Environmental Research and Public Health

Eduardo Tamayo¹  Débora Martín-García²  Francisco Herrera-Gómez³  Eduardo Gutiérrez-Abejón³  F.Javier Álvarez³ 

[1] BioCritic. Group for Biomedical Research in Critical Care Medicine, 47005 Valladolid, Spain;Department of Nephrology, Hospital Clínico Universitario de Valladolid, 47003 Valladolid, Spain;Pharmacological Big Data Laboratory, Faculty of Medicine, University of Valladolid, 47005 Valladolid, Spain;

关键词: SARS-CoV-2;    COVID-19;    clinical characteristics;    treatment;    mortality;    severe acute respiratory syndrome;   

DOI  :  10.3390/ijerph17249360

来源: DOAJ

【 摘 要 】

The first wave of the COVID-19 pandemic collapsed the hospitals in Castile and Leon (Spain). An analysis of the clinical characteristics, drug therapies and principal outcome predictors in the COVID-19 hospitalized patients from 1 March to 31 May 2020 is presented through a population-based registry study. Hospital stay variables, ventilation mode data and clinical outcomes were observed. In Castile and Leon hospitals, 7307 COVID-19 patients were admitted, with 57.05% being male and a median of 76 years. The mortality rate was 24.43%, with a high incidence of severe acute respiratory syndrome (SARS) (14.03%) and acute kidney injury (AKI) (10.87%). The most used medicines were antibiotics (90.83%), antimalarials (42.63%), steroids (44.37%) and antivirals, such as lopinavir/ritonavir (42.63%). The use of tocilizumab (9.37%) and anti-SIRS (systemic inflammatory response syndrome) medicines (7.34%) were remarkable. Fundamentally, death occurred more likely over 65 years of age (OR: 9.05). In addition, the need for ventilation was associated with a higher probability of death (OR: 3.59), SARS (OR: 5.14) and AKI (OR: 2.31). The drug-use pattern had been modified throughout the COVID-19 first wave. Multiple factors, such as age, gender and the need for mechanical ventilation, were related to the worst evolution prognosis of the disease.

【 授权许可】

Unknown