Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs Discordant for Smoking

Cancers

Rachel F. Tyndale¹  Wendy Cozen²  Otoniel Martinez-Maza³  Marta Epeldegui³  Larry Magpantay³  Thomas McCulloch Mack⁴  Amie Eunah Hwang⁴  David V. Conti⁴  Jun Wang⁴  Miina Ollikainen⁵  Jaakko Kaprio⁵ 

[1] Centre for Addiction and Mental Health, Departments of Pharmacology & Toxicology, and Psychiatry, University of Toronto, and Campbell Family Mental Health Research Institute, Toronto, ON M5S 1A8, Canada;Department of Medicine, Division of Hematology-Oncology, School of Medicine, University of California Irvine, Orange, CA 92868, USA;Department of Obstetrics and Gynecology, AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA;Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA;Department of Public Health, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland;

关键词: TARC/CCL17;    BAFF;    MCP1;    spg130;    smoking;    Hodgkin lymphoma;   

DOI  :  10.3390/cancers13215395

来源: DOAJ

【 摘 要 】

Smoking is associated with a moderate increased risk of Hodgkin and follicular lymphoma. To understand why, we examined lymphoma-related biomarker levels among 134 smoking and non-smoking twins (67 pairs) ascertained from the Finnish Twin Cohort. Previously collected frozen serum samples were tested for cotinine to validate self-reported smoking history. In total, 27 immune biomarkers were assayed using the Luminex Multiplex platform (R & D Systems). Current and non-current smokers were defined by a serum cotinine concentration of >3.08 ng/mL and ≤3.08 ng/mL, respectively. Associations between biomarkers and smoking were assessed using linear mixed models to estimate beta coefficients and standard errors, adjusting for age, sex and twin pair as a random effect. There were 55 never smokers, 43 current smokers and 36 former smokers. CCL17/TARC, sgp130, haptoglobin, B-cell activating factor (BAFF) and monocyte chemoattractant protein-1 (MCP1) were significantly (p < 0.05) associated with current smoking and correlated with increasing cotinine concentrations (P_trend < 0.05). The strongest association was observed for CCL17/TARC (P_trend = 0.0001). Immune biomarker levels were similar in former and never smokers. Current smoking is associated with increased levels of lymphoma-associated biomarkers, suggesting a possible mechanism for the link between smoking and risk of these two B-cell lymphomas.

【 授权许可】

Unknown