Translational Study on the Relationships Between Body Mass Index, Levels of Serum Inflammatory Factors and Bronchial Asthma in Children

Journal of International Translational Medicine

Xiao-bin LI¹  Ding-zhu FANG² 

[1] ;Department of Pediatric Respiration, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200093, China 2. Department of Thoracic Surgery, Shanghai Pudong New Area Gongli Hospital, Shanghai, 200135, China;

关键词: Body mass index;    Inflammatory factors;    Bronchial asthma;    Children;    Obesity;   

DOI  :  10.11910/2227-6394.2016.04.03.08

来源: DOAJ

【 摘 要 】

Objective: To explore the relationships between body mass index (BMI), levels of serum inflammatory factors and bronchial asthma in children.Methods: According to BMI, the enrolled 128 children with asthma in acute-outbreak period were assigned into obese group (n=29), skinny group (n=34) and control group (n=65). The children in three groups were all given routine treatment, including steroid aerosol, bronchodilators, fluid infusion and correction of acidosis, and returned visit after 4 weeks. The asthma control condition, levels of serum inflammatory factors, BMI and childhood asthma control test (C-ACT) scores were compared among three groups, and the relationships between C-ACT scores, BMI and levels of serum inflammatory factors were analyzed.Results: Both completely and partially controlled rates were obviously lower in obese group and skinny group than in control group (P<0.05), but there was no statistical significance between obese group and skinny group (P>0.05). The levels of serum high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were all higher in obese group than in skinny group and control group, and these indicators above in skinny group were higher than those in control group. The differences were statistically significant (P<0.05 or P<0.01). C-ACT scores increased in sequence among obese group, skinny group and control group, and the differences were statistically significant between two any groups (P<0.01). Correlation analysis revealed that C-ACT scores had a significantly negative correlation with levels of hs-CRP, IL-6 and TNF-α (r=-0.856, P=0.000; r=-0.616, P=0.000; r=-0.296, P=0.001). BMI was not correlated with C-ACT scores and levels of hs-CRP, IL-6 and TNF-α (P>0.05).Conclusion: Both obesity and emaciation can lead to increased levels of serum inflammatory factors in children with asthma, which is adverse to asthma control. Maintenance of normal body weight can effectively decrease the levels of serum inflammatory factors and improve asthma control rate.

【 授权许可】

Unknown