Microstructural changes within the basal ganglia differ between Parkinson disease subtypes

Frontiers in Neuroanatomy

Brian D Berman¹  Erika eShelton²  Justin M Honce²  Jody eTanabe²  Stefan H Sillau²  Lidia M Nagae² 

[1] Denver VA Medical Center;University of Colorado Denver Anschutz Medical Campus;

关键词: Basal Ganglia;    Diffusion Tensor Imaging;    Parkinson Disease;    Tremor dominant;    postural instability/gait difficulty;   

DOI  :  10.3389/fnana.2016.00017

来源: DOAJ

【 摘 要 】

Diffusion tensor imaging (DTI) of the substantia nigra has shown promise in detecting and quantifying neurodegeneration in Parkinson disease (PD). It remains unknown, however, whether differences in microstructural changes within the basal ganglia underlie PD motor subtypes. We investigated microstructural changes within the basal ganglia of mild to moderately affected PD patients using DTI and sought to determine if microstructural changes differ between the tremor dominant (TD) and postural instability/gait difficulty (PIGD) subtypes. Fractional anisotropy, mean diffusivity, radial and axial diffusivity were obtained from bilateral caudate, putamen, globus pallidus and substantia nigra of twenty-one PD patients (12 TD and 9 PIGD) and 20 age-matched healthy controls. T-tests and ANOVA methods were used to compare PD patients, subtypes, and controls, and Spearman correlations tested for relationships between DTI and clinical measures. We found our cohort of PD patients had reduced fractional anisotropy within the substantia nigra and increased mean and radial diffusivity within the substantia nigra and globus pallidus compared to controls, and that changes within those structures were largely driven by the PIGD subtype. Across all PD patients fractional anisotropy within the substantia nigra correlated with disease stage, while in PIGD patients increased diffusivity within the globus pallidus correlated with disease stage and motor severity. We conclude that PIGD patients have more severely affected microstructural changes within the substantia nigra compared to TD, and that microstructural changes within the globus pallidus may be particularly relevant for the manifestation of the PIGD subtype.

【 授权许可】

Unknown