Association Between Serum Furin and Fasting Glucose: A Cross-Sectional Study in Chinese Adults

Frontiers in Endocrinology

Min Zhang¹  Hanyun Zhu²  Mingzhi Zhang²  Shengqi Ma²  Jing Li³  Yin Lu³  Linan Chen³  Yan He³  Hao Peng⁴ 

[1] Central Office, Suzhou National New and Hi-Tech Industrial Development Zone Center for Disease Control and Prevention, Suzhou, China;Department of Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou, China;Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China;Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Suzhou, China;

关键词: furin;    diabetes;    fasting plasma glucose;    Chinese;    cross-sectional study;    risk factor;   

DOI  :  10.3389/fendo.2021.781890

来源: DOAJ

【 摘 要 】

BackgroundFurin has been associated with glucose metabolic phenotypes in small sampled clinical studies. However, this association has not yet been studied in Chinese. Here, we aimed to examine the association between serum furin and fasting glucose in Chinese adults.MethodsSerum furin and fasting plasma glucose were assayed for 2,172 participants (mean aged 53 years, 38% men) in the Gusu cohort. A median regression model was applied to examine the association between serum furin and fasting glucose, adjusting for age, sex, education level, cigarette smoking, alcohol drinking, obesity, blood pressure, and lipids. To facilitate data interpretation, the association between serum furin and prevalent diabetes was also examined.ResultsSerum furin was negatively associated with fasting glucose (β=-0.18, P<0.001 for log-furin). In participants with diabetes, serum furin was significantly lower than those with normal glucose (median: 0.90 ng/mL vs. 1.05 ng/mL, P=0.001). Compared with participants in the highest quartile of serum furin, those in the lowest quartile had 42% and 80% increased risk of prevalent prediabetes (OR=1.42, 95%CI: 1.05-1.92, P=0.023) and diabetes (OR=1.80, 95%CI: 1.13-2.91, P=0.015), respectively.ConclusionsSerum furin was negatively associated with prediabetes and diabetes in Chinese adults. Our findings suggest that serum furin may be a risk factor or a biomarker of diabetes.

【 授权许可】

Unknown