Metabolic Syndrome and Colorectal Cancer Risk: Results of Propensity Score-Based Analyses in a Community-Based Cohort Study

International Journal of Environmental Research and Public Health

MinKyung Lim¹  EunYoung Park²  Jin-Kyoung Oh²  Jinsun Kim²  Eunjung Park²  Byungmi Kim² 

[1] Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do 10408, Korea;Division of Cancer Prevention & Early Detection, National Cancer Control Institute, National Cancer Center, Goyang-si, Gyeonggi-do 10408, Korea;

关键词: metabolic syndrome;    colorectal cancer;    propensity score methods;    cohort;   

DOI  :  10.3390/ijerph17228687

来源: DOAJ

【 摘 要 】

Background: This study aimed to determine the effects of metabolic syndrome (MetS) on colorectal cancer (CRC) using propensity score (PS) methods. Methods: The study subjects were 2417 men and 4568 women from the Korean National Cancer Center (KNCC) Community Cohort enrolled between 2003 and 2010. Odds risks (ORs) and 95% confidence intervals (CIs) using PS matching analysis, regression models adjusted by the PS or stratified into five strata according to PS, and PS weighting methods were calculated. Results: In women, MetS and abnormally high triglyceride (TG) levels were associated with CRC risk using the PS matching analysis (ORs, for MetS, 2.19 (95% CI, 1.10–4.33); for abnormal TG levels, 2.08 (95% CI, 1.07–4.02)). However, there were no significant associations between MetS and TG levels and CRC risk in men. Conclusions: Our study might provide additional evidence that deteriorated metabolic profiles increase the risk of CRC in women rather than men. Thus, this may have an important role in effective population-level interventions for deteriorated metabolic profiles at an early stage.

【 授权许可】

Unknown