Multi-Nutrient Fortified Dairy-Based Drink Reduces Anaemia without Observed Adverse Effects on Gut Microbiota in Anaemic Malnourished Nigerian Toddlers: A Randomised Dose–Response Study

Nutrients

Folake Samuel¹  IdowuO. Senbanjo²  KazeemA. Oshikoya³  Alida Melse-Boonstra⁴  AdedotunJ. Owolabi⁵  Anne Schaafsma⁶  JeskeH. J. Hageman⁶  RobynT. Eijlander⁷  Jos Boekhorst⁷  GuusA. M. Kortman⁷ 

[1] Department of Human Nutrition, Faculty of Public Health, College of Medicine, University of Ibadan, Ibadan 200005, Nigeria;Department of Paediatrics and Child Health, Paediatric Gastroenterology, Hepatology and Nutrition Unit, Lagos State University College of Medicine, Ikeja, Lagos 100001, Nigeria;Department of Pharmacology, Therapeutic and Toxicology, Lagos State University College of Medicine, Ikeja, Lagos 100001, Nigeria;Division of Human Nutrition and Health, Wageningen University and Research, P.O. Box 17, 6700 AA Wageningen, The Netherlands;FrieslandCampina WAMCO Nigeria Plc, Industrial Estate, Plot 7b Acme Rd, Ogba, Ikeja, Lagos 100001, Nigeria;FrieslandCampina, P.O. Box 1551, 3800 BN Amersfoort, The Netherlands;NIZO Food Research B.V., 6718 ZB Ede, The Netherlands;

关键词: anaemia;    malnourished;    iron deficiency;    iron deficiency anaemia;    microbiota;    Nigeria;   

DOI  :  10.3390/nu13051566

来源: DOAJ

【 摘 要 】

Prevalence of anaemia among Nigerian toddlers is reported to be high, and may cause significant morbidity, affects brain development and function, and results in weakness and fatigue. Although, iron fortification can reduce anaemia, yet the effect on gut microbiota is unclear. This open-label randomised study in anaemic malnourished Nigerian toddlers aimed to decrease anaemia without affecting pathogenic gut bacteria using a multi-nutrient fortified dairy-based drink. The test product was provided daily in different amounts (200, 400 or 600 mL, supplying 2.24, 4.48 and 6.72 mg of elemental iron, respectively) for 6 months. Haemoglobin, ferritin, and C-reactive protein concentrations were measured to determine anaemia, iron deficiency (ID) and iron deficiency anaemia (IDA) prevalence. Faecal samples were collected to analyse gut microbiota composition. All three dosages reduced anaemia prevalence, to 47%, 27% and 18%, respectively. ID and IDA prevalence was low and did not significantly decrease over time. Regarding gut microbiota, Enterobacteriaceae decreased over time without differences between groups, whereas Bifidobacteriaceae and pathogenic E. coli were not affected. In conclusion, the multi-nutrient fortified dairy-based drink reduced anaemia in a dose-dependent way, without stimulating intestinal potential pathogenic bacteria, and thus appears to be safe and effective in treating anaemia in Nigerian toddlers.

【 授权许可】

Unknown