Fundamentals of T Cell Metabolism and Strategies to Enhance Cancer Immunotherapy

Frontiers in Immunology

Aubrey S. Smith¹  Guillermo O. Rangel Rivera¹  Amalia M. Rivera-Reyes¹  Hannah M. Knochelmann¹  Megan M. Wyatt¹  Chrystal M. Paulos¹  Connor J. Dwyer²  Jessica E. Thaxton³ 

[1] Department of Microbiology and Immunology, Emory University, Atlanta, GA, United States;Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, United States;Department of Orthopaedics and Physical Medicine, Medical University of South Carolina, Charleston, SC, United States;Department of Surgery, Emory University, Atlanta, GA, United States;

关键词: T cell metabolism;    tumor microenvironment;    adoptive T cell transfer;    immune checkpoint therapy;    tumor metabolism;    tumor infiltrating lymphocytes;   

DOI  :  10.3389/fimmu.2021.645242

来源: DOAJ

【 摘 要 】

Emerging reports show that metabolic pathways can be targeted to enhance T cell-mediated immunity to tumors. Yet, tumors consume key metabolites in the host to survive, thus robbing T cells of these nutrients to function and thrive. T cells are often deprived of basic building blocks for energy in the tumor, including glucose and amino acids needed to proliferate or produce cytotoxic molecules against tumors. Immunosuppressive molecules in the host further compromise the lytic capacity of T cells. Moreover, checkpoint receptors inhibit T cell responses by impairing their bioenergetic potential within tumors. In this review, we discuss the fundamental metabolic pathways involved in T cell activation, differentiation and response against tumors. We then address ways to target metabolic pathways to improve the next generation of immunotherapies for cancer patients.

【 授权许可】

Unknown