Bioactive selaginellins from Selaginella tamariscina (Beauv.) Spring

Beilstein Journal of Organic Chemistry

Wujiong Xia¹  Yutian Shao¹  Chao Yang¹  Kang Li¹ 

[1] State Key Lab of Urban Water Resource and Environment & the Academy of Fundamental and Interdisciplinary Sciences, Harbin Institute of Technology, Harbin 150080, PR China;

关键词: antioxidant;    cytotoxicity;    Selaginella tamariscina;    selaginellin;   

DOI  :  10.3762/bjoc.8.217

来源: DOAJ

【 摘 要 】

A new selaginellin named selaginellin O (1), along with three other known selaginellins (2–4) were isolated from Selaginella tamariscina (Beauv.) Spring. On the basis of spectroscopic analysis, the structure of selaginellin O was demonstrated to be 4-[(4’-hydroxy-4-formyl-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)(4-hydroxyphenyl)methylene]cyclohexa-2,5-dien-1-one. Compound 1, 2 and 3 exhibited appreciable cytotoxic activity against cultured HeLa cells (human cervical carcinoma cells), as well as significant antioxidant activity.

【 授权许可】

Unknown