Toxicological Evaluation ofTetrameles nudifloraMethanolic Extract

Journal of Tropical Life Science

Indah D Dewijanti¹  Megawati¹  Marissa Angelina¹  Sofna DS Banjarnahor¹  Sofa Fajriah¹ 

[1] Research Center for Chemistry, Indonesian Institute of Sciences (LIPI) Kawasan Puspiptek, Tangerang Selatan, Banten, Indonesia ;

关键词: acute oral toxicity;    brine shrimp lethality test;    LD 50;    Tetrameles nudiflora;   

DOI  :  

来源: DOAJ

【 摘 要 】

Exploration of Mekongga national park resulted in novel finding of anticancer property from Tetrameles nudiflora. The investigation of toxic features of T. nudiflora is vital for further studies of its pharmacological activities. Acute toxicity test was done on methanolic extracts of T. nudiflora in DDY mice. Animal models were ordered into five groups. Group 1 was given 1 ml solution of 2.5% Tween 80 in a sole oral dose. The remaining groups were appointed a sole dose of 1, 2, 4 and 8 g/kg body weight T. nudiflora, respectively. Toxic effects of the extract were evaluated on the basis of behavioral observations in the form of locomotor activity; curiosity; defecation; urination and also animal mortality. Observations were carried out for 14 days. No significant changes in body weight and behavioral activities were recorded. Mortality was recorded up to 22% of the male group, and 11% of the female group. The T. nudiflora extracts tested for toxicity against brine shrimp had 50% lethal concentration (LC50) values of 46.67 μg/ml. It can be concluded that methanol extracts of T. nudiflora are potential to be explored as anticancer (LC50= 46.67 μg/ml). The extract is slightly toxic in male mice with Lethal Dose 50 (LD50) 12.6 g/kg body weight, and practically nontoxic for female (LD50>15 g/kg body weight)

【 授权许可】

Unknown