The Development of Light-Curable Calcium-Silicate-Containing Composites Used in Odontogenic Regeneration

Polymers

Chia-Che Ho¹  Ming-You Shie²  Yi-Ting Lin³  Chia-Tze Kao³  Tsui-Hsien Huang³  Yen-Hong Lin⁴ 

[1] Department of Bioinformatics and Medical Engineering, Asia University, Taichung 41354, Taiwan;School of Dentistry, China Medical University, Taichung 406040, Taiwan;School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan;The Ph.D. Program for Medical Engineering and Rehabilitation Science, China Medical University, Taichung 406040, Taiwan;

关键词: calcium silicate;    polyethylene glycol diacrylate;    light curing;    dental pulp stem cells;    odontogenesis;   

DOI  :  10.3390/polym13183107

来源: DOAJ

【 摘 要 】

Pulp regeneration is one of the most successful areas in the field of tissue regeneration, despite its current limitations. The biocompatibility of endodontic biomaterials is essential in securing the oral microenvironment and supporting pulp tissue regeneration. Therefore, the objective of this study was to investigate the new light-curable calcium silicate (CS)-containing polyethylene glycol diacrylate (PEGDA) biocomposites’ regulation of human dental pulp stem cells (hDPSCs) in odontogenic-related regeneration. The CS-containing PEGDA (0 to 30 wt%) biocomposites are applied to endodontics materials to promote their mechanical, bioactive, and biological properties. Firstly, X-ray diffraction and Fourier-transform infrared spectroscopy showed that the incorporation of CS increased the number of covalent bonds in the PEGDA. The diameter tension strength of the CS-containing PEGDA composite was significantly higher than that of normal PEGDA, and a different microstructure was detected on the surface. Samples were analyzed for their surface characteristics and Ca/Si ion-release profiles after soaking in simulated body fluid for different periods of time. The CS30 group presented better hDPSC adhesion and proliferation in comparison with CS0. Higher values of odontogenic-related biomarkers were found in hDPSCs on CS30. Altogether, these results prove the potential of light-curable CS-containing PEGDA composites as part of a ‘point-of-care’ strategy for application in odontogenesis-related regeneration.

【 授权许可】

Unknown