Genomic Analysis of 18th-Century Kazakh Individuals and Their Oral Microbiome

Biology

Davide Pettener¹  Elisabetta Cilli²  Donata Luiselli²  Gian Luca Bonora³  Carles Lalueza-Fox⁴  Pablo Carrión⁴  Esther Lizano⁴  Laia Llovera⁴  Iñigo Olalde⁴  Anna E. White⁴  Toni de-Dios⁴  Tomàs Marquès-Bonet⁴  Maral K. Khabdulina⁵  Daniyar T. Tleugabulov⁵  Lucy van Dorp⁶  François Balloux⁶ 

[1] Department of Biological, Geological and Environmental Sciences, University of Bologna, 40126 Bologna, Italy;Department of Cultural Heritage, University of Bologna, 48121 Ravenna, Italy;ISMEO—International Association for Mediterranean and East Studies, 00186 Rome, Italy;Institute of Evolutionary Biology, CSIC-Universitat Pompeu Fabra, 08003 Barcelona, Spain;K.A. Akishev Institute of Archaeology, L.N. Gumilev Eurasian National University, Nur-Sultan 010000, Kazakhstan;UCL Genetics Institute, Department of Genetics Evolution & Environment, University College London, London WC1E 6BT, UK;

关键词: paleogenomics;    ancient pathogens;    Central Asian steppe;    red complex;    bacteria;   

DOI  :  10.3390/biology10121324

来源: DOAJ

【 摘 要 】

The Asian Central Steppe, consisting of current-day Kazakhstan and Russia, has acted as a highway for major migrations throughout history. Therefore, describing the genetic composition of past populations in Central Asia holds value to understanding human mobility in this pivotal region. In this study, we analyse paleogenomic data generated from five humans from Kuygenzhar, Kazakhstan. These individuals date to the early to mid-18th century, shortly after the Kazakh Khanate was founded, a union of nomadic tribes of Mongol Golden Horde and Turkic origins. Genomic analysis identifies that these individuals are admixed with varying proportions of East Asian ancestry, indicating a recent admixture event from East Asia. The high amounts of DNA from the anaerobic Gram-negative bacteria Tannerella forsythia, a periodontal pathogen, recovered from their teeth suggest they may have suffered from periodontitis disease. Genomic analysis of this bacterium identified recently evolved virulence and glycosylation genes including the presence of antibiotic resistance genes predating the antibiotic era. This study provides an integrated analysis of individuals with a diet mostly based on meat (mainly horse and lamb), milk, and dairy products and their oral microbiome.

【 授权许可】

Unknown