EFFECTS OF LOW-INTENSITY MICROWAVE IRRADIATION UPON INTRACELLULAR SIGNALING OF MONONUCLEAR CELLS IN PNEUMONIA PATIENTS

Medicinskaâ Immunologiâ

V. K. Parfenyk¹  V. S. Nikiforov²  S. S. Bondar³  I. V. Terekhov⁴  M. S. Gromov⁵  K. A. Solodukhin⁵ 

[1] ГБОУ ВПО «Саратовский государственный медицинский университет им. В.И. Разумовского»Минздравсоцразвития РФ, г. Саратов;ГБОУ ВПО «Северо-Западный государственный медицинский университет им. И.И. Мечникова»Минздравсоцразвития РФ, Санкт-Петербург;ГБУЗ ГКБ № 8, г. Саратов;ООО «Телемак», г. СаратовГБОУ ВПО «Саратовский государственный медицинский университет им. В.И. Разумовского»Минздравсоцразвития РФ, г. Саратов;Саратовский филиал НГОУ ВПО Самарский медицинский институт «РЕАВИЗ», г. Саратов;

关键词: microwave radiation;    mononuclear cells;    cytokines;    transcription factors;    pneumonia;   

DOI  :  10.15789/1563-0625-2012-6-541-544

来源: DOAJ

【 摘 要 】

Abstract. Some molecular biomarkers of peripheral blood mononuclear cells (PBMC) were studied in patients 18 to 30 years old with community-acquired pneumonia (n = 30) and healthy persons (n = 15), along with testing appropriate biological effects of low-intensity microwave irradiation (1000 MHz), at a dose rate of 100 pW/cm2. Concentrations of cytokines and some molecules providing intracellular signal transduction in PBMC were measured by ELISA tests. Biological action of microwave radiation was studied after 1-hour irradiation of whole blood, followed by incubation for 24 hours. A single round of irradiation was shown to cause an increase in NFκB content by 12.5% (р = 0.001); IκB by 21.1% (р = 0.0007); phosphorylated JNK1/2, by 18.2% (р = 0.052); p21 protein amounts, by 56.2% (р = 0.031); IL-2, by 8.5% (р = 0.08); IL-4, by 17.6% (р = 0.031). Antioxidant potential of PBMC supernatewas augmented by 65.2% (р < 0,001). Hence, a single 1000-MHz microwave irradiation modulates activity of intracellular events in PBMCs from pneumonia patients.

【 授权许可】

Unknown