Serum Growth Differentiation Factor 15 Levels Are Associated With Depression After Ischemic Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Jieyun Yin¹  Yonghong Zhang¹  Yi Xie¹  Xiaoqing Bu¹  Zhen Liu¹  Aili Wang¹  Zhengbao Zhu¹  Kaixin Zhang¹  Pinni Yang¹  Yuhan Zang¹  Jing Chen²  Jiang He² 

[1] Department of Epidemiology School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases Medical College of Soochow University Suzhou China;Department of Epidemiology Tulane University School of Public Health and Tropical Medicine New Orleans LA;

关键词: acute ischemic stroke;    growth differentiation factor 15;    Hamilton rating scale for depression;    poststroke depression;   

DOI  :  10.1161/JAHA.121.022607

来源: DOAJ

【 摘 要 】

Background The effect of serum growth differentiation factor 15 (GDF‐15) on poststroke depression (PSD) remains unknown. This study aimed to investigate the association between serum GDF‐15 and PSD among patients with ischemic stroke. Methods and Results This study was based on a random sample from CATIS (China Antihypertensive Trial in Acute Ischemic Stroke). A total of 572 patients from 7 participating hospitals with GDF‐15 levels were included in this analysis. The study outcome was depression (Hamilton Depression Rating Scale score ≥8) at 3 months after ischemic stroke. A total of 231 (40.4%) patients with stroke experienced PSD within 3 months. The multivariate‐adjusted odds ratio of PSD associated with the highest tertile of serum GDF‐15 was 2.92 (95% CI, 1.36–6.27) compared with the lowest tertile. Each SD increase in log‐transformed GDF‐15 was associated with a 42% (95% CI, 2%–97%) increased risk of PSD, and a linear association between serum GDF‐15 and the risk of PSD was observed (P for linearity=0.006). Conclusions Elevated serum GDF‐15 levels in the acute phase of ischemic stroke were independently associated with PSD, suggesting that GDF‐15 may be a valuable prognostic biomarker for PSD.

【 授权许可】

Unknown