A novel approach to monitoring the efficacy of anti-tumor treatments in animal models: combining functional MRI and texture analysis

BMC Cancer

Haiyan Xu¹  Jingjuan Liu²  Zhengyu Jin²  Jing Lei²  Qin Wang²  Ming Meng²  Huadan Xue²  Yuan Li²  Ting Sun² 

[1] Department of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Basic Medical Sciences;Department of Radiology, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital;

关键词: Breast cancer;    Neoadjuvant chemotherapy;    Functional MRI;    Texture analysis;    Multiparameter imaging;   

DOI  :  10.1186/s12885-018-4684-z

来源: DOAJ

【 摘 要 】

Abstract Background The aim of this study was to evaluate the early anti-tumor efficiency of different therapeutic agents with a combination of multi-b-value DWI, DCE-MRI and texture analysis. Methods Eighteen 4 T1 homograft tumor models were divided into control, paclitaxel monotherapy and paclitaxel and bevacizumab combination therapy groups (n = 6) that underwent multi-b-value DWI, DCE-MRI and texture analysis before and 15 days after treatment. Results After treatment, the tumors in the control group were significantly larger than those in the combination group (P = 0.018). In multi-b-value DWI, the ADCslow obviously increased in the combination group compared to that in the others (P < 0.01). The f increased in the control and paclitaxel groups, but the combination group showed a significant decrease versus the others (P < 0.02). Additionally, in DCE-MRI, the decreasing Ktrans showed an evident difference between the combination and control groups (P = 0.003) due to the latter’s increasing Ktrans. The intra-group comparisons of tumor texture in pre-, mid- and post-treatments showed that the entropy had all significantly increased in all groups (P < 0.01, SSF = 0–6), though the MPP, mean and SD increased only in the combination group (PMPP,mean,SD < 0.05, SSF = 4–6). Moreover, the inter-group comparisons revealed that the mean and MPP exhibited significant differences after treatment (Pmean,MPP  < 0.05, SSF = 0–3). Conclusion All these results suggest some strong correlations among DWI, DCE and texture analysis, which are beneficial for further study and clinical research.

【 授权许可】

Unknown