HLA-DRB and HLA-DQB Allele and Haplotype Frequenciesin Iranian Patients with Recurrent Aphthous Stomatitis

Iranian Journal of Allergy, Asthma and Immunology

Shamsolmoulouk Najafi¹  Nima Rezaei²  Mahsa Mohammadzadeh³  Ghasem Meighani⁴  Alireza Zare Bidoki⁵  Mahdi Mahmoudi⁶  Saeed Aslani⁷ 

[1] Dental Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran;Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran AND Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran AND Universal Scientific Education and Research Network (USERN), Tehran, Iran;Department of Orthodontic, Dental Branch, Islamic Azad University, Tehran, Iran;Department of Pediatrics , School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran;Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran AND Thrombosis Hemostasis Research Center, Tehran University of Medical Sciences, Tehran, Iran;Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran;Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;

关键词: Allele frequency;    Haplotype frequency;    Human leukocyte antigen;    Recurrent aphthous stomatitis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Recurrent aphthous stomatitis (RAS) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. RAS appears to be associated with some human leukocyte antigen (HLA) class II alleles and haplotypes. This study attempts to survey the distribution of HLA-DRB and -DQB alleles among Iranian RAS patients and healthy controls. In order to evaluate the association of HLA-DR and DQ alleles and haplotypes, 54 patients with RAS and 100 unrelated healthy subjects as control group were investigated. Our data indicated that DRB1*13:17, DRB1*15:01, and DRB5*01 were significantly more frequent in RAS patients in comparison to controls. However, DRB3:01allele frequency was higher in the controls compared to the patients. The significantly frequent allele in the patients compared with the healthy subjects was HLA-DQB1*03:02. However, both HLA-DQB1*02:01 and HLA-DQB1*03:01 alleles were most frequent in the healthy individuals rather than the patients. The DRB*04/DQB1*03:01 and DRB*01:01/DQB1*02:01 haplotypes were significantly distributed in healthy subjects compared with patients. However, DRB*07:01/DQB1*03:02 haplotype was found to be significantly frequent in patients than controls. In respect of HLA genes, factors are involved in the incidence of RAS; various HLA-DRB and HLA-DQB1 alleles and the related haplotypes are suggested to be the three main RAS susceptibility factors in our population study.

【 授权许可】

Unknown