The exposome in practice: an exploratory panel study of biomarkers of air pollutant exposure in Chinese people aged 60–69 years (China BAPE Study)

Environment International

Renjie Chen¹  Tiantian Li¹  Xiaoming Shi²  Jianlong Fang³  Mu Zhu³  Yi Zhang³  Yuanyuan Chen³  Yu'e Cha³  Tianwei Yu³  David C. Thompson³  Song Tang³  Yanjun Du³  Vasilis Vasiliou⁴  Haidong Kan⁵  John S. Ji⁵  Junfeng Jim Zhang⁶  Krystal J. Godri Pollitt⁷  Yanwen Wang⁸ 

[1] Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China;;Global Health Institute &China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China;Department of Clinical Pharmacy, School of Pharmacy, University of Colorado, Aurora, CO 80045, USA;Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT 06520, USA;Environmental Research Center, Duke Kunshan University, Kunshan, Jiangsu 215316, China;Institute for Data and Decision Analytics, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China;School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai 200032, China;

关键词: PM2.5;    Exposomics;    Panel Study;    Personal Exposure Monitoring;    Metabolomics;    Exposome-Wide Association Study;   

DOI  :  

来源: DOAJ

【 摘 要 】

The exposome overhauls conventional environmental health impact research paradigms and provides a novel methodological framework that comprehensively addresses the complex, highly dynamic interplays of exogenous exposures, endogenous exposures, and modifiable factors in humans. Holistic assessments of the adverse health effects and systematic elucidation of the mechanisms underlying environmental exposures are major scientific challenges with widespread societal implications. However, to date, few studies have comprehensively and simultaneously measured airborne pollutant exposures and explored the associated biomarkers in susceptible healthy elderly subjects, potentially resulting in the suboptimal assessment and management of health risks. To demonstrate the exposome paradigm, we describe the rationale and design of a comprehensive biomarker and biomonitoring panel study to systematically explore the association between individual airborne exposure and adverse health outcomes. We used a combination of personal monitoring for airborne pollutants, extensive human biomonitoring, advanced omics analysis, confounding information, and statistical methods. We established an exploratory panel study of Biomarkers of Air Pollutant Exposure in Chinese people aged 60–69 years (China BAPE), which included 76 healthy residents from a representative community in Jinan City, Shandong Province. During the period between September 2018 and January 2019, we conducted prospective longitudinal monitoring with a 3-day assessment every month. This project: (1) leveraged advanced tools for personal airborne exposure monitoring (external exposures); (2) comprehensively characterized biological samples for exogenous and endogenous compounds (e.g., targeted and untargeted monitoring) and multi-omics scale measurements to explore potential biomarkers and putative toxicity pathways; and (3) systematically evaluated the relationships between personal exposure to air pollutants, and novel biomarkers of exposures and effects using exposome-wide association study approaches. These findings will contribute to our understanding of the mechanisms underlying the adverse health impacts of air pollution exposures and identify potential adverse clinical outcomes that can facilitate the development of effective prevention and targeted intervention techniques.

【 授权许可】

Unknown