The Effect of Essential Oil of Lavandula Angustifolia on Amyloid Beta Polymerization: An In Vitro Study

Iranian Journal of Chemistry & Chemical Engineering

Mehdi Mirhashemi¹  Masoud Soheili²  Mahmoud Salami³  Farzaneh Khalaji⁴ 

[1] Clinical Biochemistry and Genetics Department, School of Medicine, Qazvin University of Medical Sciences, Qazvin, I.R. IRAN;Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I.R. IRAN +Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, ashan, I.R. IRAN;Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. IRAN;Research Center for Biochemistry and Nutrition in Metabolic Diseases,Kashan University of Medical Sciences, Kashan, I.R. IRAN;

关键词: alzheimer’s disease;    amyloid-beta;    aggregation;    lavender;    essential oil;   

DOI  :  

来源: DOAJ

【 摘 要 】

Alzheimer’s Disease (AD) is a progressive neurological disorder associated with cognitive and memory deficits. Accumulation of amyloid beta (Aβ) plaques is one of the major causes of AD. Therefore, inhibition of the plaque formation has been aimed to play a preventive role in the disease. Lavender, through some neuroprotective roles such as antioxidant effects, is known to be an effective candidate in the treatment of neurodegenerative disorders. In this study using Thioflavin T Measurement and Atomic Force Microscope (AFM) Imaging, we evaluated the effect of essential oil of lavender on Aβ polymerization. Thioflavin T Method showed that essential oil enhances the Aβ aggregation. The results of the AFM method also confirmed it. Our data antagonizes previous results indicating the clearing effect of aqueous extract of lavender on Aβ plaque. It seems that the different combination of essential oil and aqueous extract considerably determines if or not the aggregation occurs.

【 授权许可】

Unknown