Calcium Homeostasis in ageing neurons

Frontiers in Genetics

Nektarios eTavernarakis¹  Vassiliki eNikoletopoulou¹ 

[1] University of Crete, Foundation for Research and Technology-Hellas;

关键词: Endoplasmic Reticulum;    Long-Term Potentiation;    Mitochondria;    synaptic plasticity;    Golgi;    ion channel;   

DOI  :  10.3389/fgene.2012.00200

来源: DOAJ

【 摘 要 】

The nervous system becomes increasingly vulnerable to insults and prone to dysfunction during ageing. Age-related decline of neuronal function is manifested by the late onset of many neurodegenerative disorders, as well as by reduced signalling and processing capacity of individual neuron populations. Recent findings indicate that impairment of Ca2+ homeostasis underlies the increased susceptibility of neurons to damage, associated with the ageing process. However, the impact of ageing on Ca2+ homeostasis in neurons remains largely unknown. Here, we survey the molecular mechanisms that mediate neuronal Ca2+ homeostasis and discuss the impact of ageing on their efficacy. To address the question of how ageing impinges on Ca2+ homeostasis, we consider potential nodes through which mechanisms regulating Ca2+ levels interface with molecular pathways known to influence the process of ageing and senescent decline. Delineation of this crosstalk would facilitate the development of interventions aiming to fortify neurons against age-associated functional deterioration and death by augmenting Ca2+ homeostasis.

【 授权许可】

Unknown