Gamma irradiation-mediated inactivation of enveloped viruses with conservation of genome integrity: Potential application for SARS-CoV-2 inactivated vaccine development

Open Life Sciences

Abolaban Fouad A.¹  Djouider Fathi M.¹ 

[1] Nuclear Engineering Department, Faculty of Engineering, King Abdulaziz University, PO Box 80204, Jeddah, 21589, Saudi Arabia;

关键词: sars-cov-2 virus;    virus genome;    virus infectivity;    gamma irradiation;    virus inactivation;    vaccine development;   

DOI  :  10.1515/biol-2021-0051

来源: DOAJ

【 摘 要 】

Radiation inactivation of enveloped viruses occurs as the result of damages at the molecular level of their genome. The rapidly emerging and ongoing coronavirus disease 2019 (COVID-19) pneumonia pandemic prompted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a global health crisis and an economic devastation. The readiness of an active and safe vaccine against the COVID-19 has become a race against time in this unqualified global panic caused by this pandemic. In this review, which we hope will be helpful in the current situation of COVID-19, we analyze the potential use of γ-irradiation to inactivate this virus by damaging at the molecular level its genetic material. This inactivation is a vital step towards the design and development of an urgently needed, effective vaccine against this disease.

【 授权许可】

Unknown