Roles of active forms of vitamin D in supporting innate immune systems and in reducing excess inflammation in COVID-19

Терапевтический архив

Olga A. Gromova¹  Ivan I. Torshin¹  Elena N. Kozhevnikova²  Svetlana I. Malyavskaya³  Alexander G. Chuchalin⁴ 

[1] Computer Science and Control;Institute of General Pathology and Pathophysiology;Northern State Medical University;Pirogov Russian National Research Medical University;

关键词: covid-19;    antiviral immunity;    micronutrients;    alfacalcidol;   

DOI  :  10.26442/00403660.2021.08.200918

来源: DOAJ

【 摘 要 】

A reduced supply of micronutrient vitamin D leads to a more severe course of coronavirus infection (COVID-19). Vitamin D deficiency is combined with a decrease in innate antiviral immunity and excess of inflammation. Vitamin D supplementation stimulates the synthesis of antibacterial peptides and is important for weakening the cytokine storm, reducing excessive acute and chronic inflammation, and also for compensating for chronic comorbid pathologies. Active forms of vitamin D (alfacalcidol, etc.) are of particular importance for compensating for vitamin D deficiency in elderly patients, endocrine-immune dysfunction, sarcopenia, chronic renal failure (in which the metabolism of vitamin D in the kidneys is disturbed).

【 授权许可】

Unknown