Stable Formulations of Peptide-Based Nanogels

Molecules

Elisabetta Rosa¹  Antonella Accardo¹  Carlo Diaferia¹  Giancarlo Morelli¹  Enrico Gallo² 

[1] Department of Pharmacy and Interuniversity Research Centre on Bioactive Peptides (CIRPeB), University of Naples “Federico II”, via Mezzocannone 16, 80134 Naples, Italy;IRCCS SDN, Via E. Gianturco 113, 80143 Naples, Italy;

关键词: peptide-based nanogels;    inverse emulsion;    nanogel formulation;    hydrogel nanoparticles;    diagnostic imaging;    peptide aggregates;   

DOI  :  10.3390/molecules25153455

来源: DOAJ

【 摘 要 】

Recently, nanogels have been identified as innovative formulations for enlarging the application of hydrogels (HGs) in the area of drug delivery or in diagnostic imaging. Nanogels are HGs-based aggregates with sizes in the range of nanometers and formulated in order to obtain injectable preparations. Regardless of the advantages offered by peptides in a hydrogel preparation, until now, only a few examples of peptide-based nanogels (PBNs) have been developed. Here, we describe the preparation of stable PBNs based on Fmoc-Phe-Phe-OH using three different methods, namely water/oil emulsion (W/O), top-down, and nanogelling in water. The effect of the hydrophilic–lipophilic balance (HLB) in the formulation was also evaluated in terms of size and stability. The resulting nanogels were found to encapsulate the anticancer drug doxorubicin, chosen as the model drug, with a drug loading comparable with those of the liposomes.

【 授权许可】

Unknown