Amino-Li-Resin—A Fiber Polyacrylamide Resin for Solid-Phase Peptide Synthesis

Polymers

Yongfu Li¹  Beatriz G. de la Torre²  Damilola C. Akintayo³  Fernando Albericio³ 

[1] Biotide Core, LLC, 33815 SE Eastgate Circle, Corvallis, OR 97333, USA;KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa;Peptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Westville, Durban 4000, South Africa;

关键词: amino-Li-resin;    solid-phase peptide synthesis;    polyacrylamide;    fibers;   

DOI  :  10.3390/polym14050928

来源: DOAJ

【 摘 要 】

Amino-Li-resin is a new and unique polyacrylamide resin presented in the form of fibers and is found to be well suited for solid-phase peptide chemistry. Although amino-Li-resin swells much better in polar solvents, it is also compatible with some non-polar solvents. It comes with a high loading of functional amino groups, thus maximizing its productivity in terms of the amount of peptide per gram of resin. In addition to its mechanical stability, this resin shows excellent stability in basic and acidic reagents; thus, allowing its broad applicability for the synthesis of a wide range of biomolecules. Finally, the appropriateness of amino-Li-resin for solid-phase peptide synthesis (SPPS) has been demonstrated for the synthesis of several model peptides, including difficult sequences and those containing hindered amino acids, all of which afforded excellent crude purity, as shown by high-performance liquid chromatography (HPLC) analysis.

【 授权许可】

Unknown