Clinical polyneuropathy does not increase with prediabetes or metabolic syndrome in the Japanese general population

Journal of Diabetes Investigation

Seigo Kurisu¹  Kazuhiro Hirayasu¹  Hideyuki Sasaki²  Takashi Akamizu³  Shohei Matsuno³  Shohei Kishimoto³  Hiroto Furuta³  Mikio Arita⁴  Kinichi Ogawa⁵  Keigo Naka⁶  Kishio Nanjo⁶ 

[1] Department of Medicine Kihoku HospitalWakayama Medical UniversityWakayamaJapan;Division of Diabetes and Metabolism Satellite Clinic for Integrative and Anti‐Aging Medicine Wakayama Medical University WakayamaJapan;First Department of Medicine Wakayama Medical University Wakayama Japan;Health‐promotion Research Center Wakayama Japan;Kansai University of Health Sciences Osaka Japan;Wakayama Rosai Hospital WakayamaJapan;

关键词: Metabolic syndrome;    Prediabetes;    Prevalence of symmetric sensorimotor polyneuropathy;   

DOI  :  10.1111/jdi.13058

来源: DOAJ

【 摘 要 】

Abstract Aims/Introduction The prevalence of clinical polyneuropathies (ClinPNs) or nerve conduction abnormality (NCA) in the groups stratified by glucose tolerance, individual components of metabolic syndrome (metabolic syndrome [MetS] components: hypertension, dyslipidemia, obesity) and MetS defined by the International Diabetes Federation consensus was investigated in the Japanese general population. Factors associated with ClinPN and NCA were also identified. Materials and Methods A total of 625 examinees of regional medical checkup programs were recruited to this cross‐sectional study. ClinPNs were diagnosed by the Toronto Consensus. NCA was judged by at least one bilateral abnormality of sural nerve action potential amplitude or conduction velocity measured by a point‐of‐care nerve conduction device (DPNCheck). Clinical factors associated with ClinPNs or NCA were examined by multiple logistic regression analysis. Deteriorating factors of sural nerve action potential amplitude or conduction velocity values were also investigated in participants without diabetes (n = 550). Results As for glucose tolerance, ClinPNs or NCA significantly increased only in known diabetes patients compared with other groups. There was no difference between prediabetes and the normal group. The prevalence of ClinPNs and NCA was not significantly related to MetS or MetS’ components, except for frequent NCA in obesity. The factors significantly associated with both NCA and ClinPNs were smoking and known diabetes. In non‐diabetic participants, aging, tall height and hypertension were significant deteriorating factors of nerve conduction functions. Conclusions In Japan, ClinPNs and NCA were increased in known diabetes patients, but did not increase in participants with prediabetes, MetS and MetS’ components. Smoking and known diabetes were factors significantly associated with ClinPNs or NCA. Hypertension might be a modifiable deteriorating factor of nerve function.

【 授权许可】

Unknown