Modulation of Gamma Spectral Amplitude and Connectivity During Reaching Predicts Peak Velocity and Movement Duration

Frontiers in Neuroscience

Angelo Quartarone¹  Alberto Cacciola¹  Francesca Ferraioli²  Elisa Tatti²  Maria Felice Ghilardi²  Cameron Chan² 

[1] Department of Biomedical, Dental Sciences and Morphological and Functional Images, University of Messina, Messina, Italy;Department of Molecular, Cellular and Biomedical Sciences, City University of New York (CUNY), School of Medicine, New York, NY, United States;

关键词: motor control;    EEG;    gamma oscilations;    event-related synchronization;    phase coherence;    reaching movement;   

DOI  :  10.3389/fnins.2022.836703

来源: DOAJ

【 摘 要 】

Modulation of gamma oscillations recorded from the human motor cortex and basal ganglia appears to play a key role in movement execution. However, there are still major questions to be answered about the specific role of cortical gamma activity in both the planning and execution of movement features such as the scaling of peak velocity and movement time. In this study, we characterized movement-related gamma oscillatory dynamics and its relationship with kinematic parameters based on 256-channels EEG recordings in 64 healthy subjects while performing fast and uncorrected reaching movements to targets located at three distances. In keeping with previous studies, we found that movement-related gamma synchronization occurred during movement execution. As a new finding, we showed that gamma synchronization occurred also before movement onset, with planning and execution phases involving different gamma peak frequencies and topographies. Importantly, the amplitude of gamma synchronization in both planning and execution increased with target distance and predicted peak velocity and movement time. Additional analysis of phase coherence revealed a gamma-coordinated long-range network involving occipital, frontal and central regions during movement execution that was positively related to kinematic features. This is the first evidence in humans supporting the notion that gamma synchronization amplitude and phase coherence pattern can reliably predict peak velocity amplitude and movement time. Therefore, these findings suggest that cortical gamma oscillations have a crucial role for the selection, implementation and control of the appropriate kinematic parameters of goal-directed reaching movements.

【 授权许可】

Unknown