Coenzyme Q10: Clinical Applications in Cardiovascular Diseases

Antioxidants

Alma Martelli¹  Lara Testai¹  Alessandro Colletti²  ArrigoF. G. Cicero³ 

[1] Department of Pharmacy, University of Pisa, 56120 Pisa, Italy;Department of Science and Drug Technology, University of Turin, 10125 Turin, Italy;Italian Nutraceutical Society (SINut), Via Guelfa 9, 40138 Bologna, Italy;

关键词: coenzyme Q₁₀;    ubiquinone;    cardiovascular disease;    risk factors;    prevention;    supplementation;   

DOI  :  10.3390/antiox9040341

来源: DOAJ

【 摘 要 】

Coenzyme Q₁₀ (CoQ₁₀) is a ubiquitous factor present in cell membranes and mitochondria, both in its reduced (ubiquinol) and oxidized (ubiquinone) forms. Its levels are high in organs with high metabolism such as the heart, kidneys, and liver because it acts as an energy transfer molecule but could be reduced by aging, genetic factors, drugs (e.g., statins), cardiovascular (CV) diseases, degenerative muscle disorders, and neurodegenerative diseases. As CoQ₁₀ is endowed with significant antioxidant and anti-inflammatory features, useful to prevent free radical-induced damage and inflammatory signaling pathway activation, its depletion results in exacerbation of inflammatory processes. Therefore, exogenous CoQ₁₀ supplementation might be useful as an adjuvant in the treatment of cardiovascular diseases such as heart failure, atrial fibrillation, and myocardial infarction and in associated risk factors such as hypertension, insulin resistance, dyslipidemias, and obesity. This review aims to summarize the current evidences on the use of CoQ₁₀ supplementation as a therapeutic approach in cardiovascular diseases through the analysis of its clinical impact on patients’ health and quality of life. A substantial reduction of inflammatory and oxidative stress markers has been observed in several randomized clinical trials (RCTs) focused on several of the abovementioned diseases, even if more RCTs, involving a larger number of patients, will be necessary to strengthen these interesting findings.

【 授权许可】

Unknown