Cellular Origin(s) of Congenital Diaphragmatic Hernia

Frontiers in Pediatrics

Gerben Schaaf¹  Robbert J. Rottier²  Gabriëla G. Edel²  Gabrielle Kardon⁴  Rene M. H. Wijnen⁵  Dick Tibboel⁵ 

[1] Center for Lysosomal and Metabolic Diseases, Erasmus MC, Rotterdam, Netherlands;Department of Cell Biology, Erasmus MC, Rotterdam, Netherlands;Department of Clinical Genetics, Erasmus MC, Rotterdam, Netherlands;Department of Human Genetics, University of Utah, Salt Lake City, UT, United States;Department of Pediatric Surgery and Intensive Care, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands;Department of Pediatrics, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands;

关键词: congenital diaphragmatic hernia (CDH);    diaphragm;    pleuroperitoneal folds;    perivascular cells;    mesothelium;   

DOI  :  10.3389/fped.2021.804496

来源: DOAJ

【 摘 要 】

Congenital diaphragmatic hernia (CDH) is a structural birth defect characterized by a diaphragmatic defect, lung hypoplasia and structural vascular defects. In spite of recent developments, the pathogenesis of CDH is still poorly understood. CDH is a complex congenital disorder with multifactorial etiology consisting of genetic, cellular and mechanical factors. This review explores the cellular origin of CDH pathogenesis in the diaphragm and lungs and describes recent developments in basic and translational CDH research.

【 授权许可】

Unknown