An alternative synthesis of (+) - propranolol and (+) – atenolol

Maejo International Journal of Science and Technology

关键词: beta-blockers;    propranolol;    atenolol;   

DOI  :  

来源: DOAJ

【 摘 要 】

Herein, a simple synthesis pathway of beta-blockers starting from allyl amine ispresented. This synthesis features the opening of an epoxide ring with phenol derivatives followed by N-alkylation with iso-propylbromide to produce racemic propranolol and atenolol.

【 授权许可】

Unknown