Inflammasomes as Targets for Adjuvants

Pathogens

Konstantin Ivanov¹  Svetlana Khaiboullina¹  Ekaterina Garanina¹  Albert Rizvanov¹ 

[1] Kazan Federal University, 420008 Kazan, Russia;

关键词: vaccines;    adjuvants;    inflammasomes;    innate immunity;    cytokines;   

DOI  :  10.3390/pathogens9040252

来源: DOAJ

【 摘 要 】

Inflammasomes are an essential part of the innate immune system. They are necessary for the development of a healthy immune response against infectious diseases. Inflammasome activation leads to the secretion of pro-inflammatory cytokines such as IL-1β and IL-18, which stimulate the adaptive immune system. Inflammasomes activators can be used as adjuvants to provide and maintain the strength of the immune response. This review is focused on the mechanisms of action and the effects of adjuvants on inflammasomes. The therapeutic and prophylaxis significance of inflammasomes in infectious diseases is also discussed.

【 授权许可】

Unknown