E-I balance and human diseases - from molecules to networking

Frontiers in Molecular Neuroscience

Jochen C Meier¹  Sabrina A Eichler¹ 

[1] RNA Editing and Hyperexcitability Disorders Helmholtz Group, Max Delbrück Center for Molecular Medicine;

关键词: excitation;    inhibition;    mental retardation;    Schizophrenia;    Alzheimerï;    ASD autism spectrum disorders;   

DOI  :  10.3389/neuro.02.002.2008

来源: DOAJ

【 摘 要 】

Information transfer in the brain requires a homeostatic control of neuronal excitability. Therefore, a functional balance between excitatory and inhibitory systems is established during development. This review contains recent information about the molecular mechanisms orchestrating the establishment and maintenance of this excitation-inhibition (E-I) balance, and it reviews examples of deregulation of inhibitory and excitatory systems at a molecular, network and disease level of investigation.

【 授权许可】

Unknown