Evasion before invasion: Pre-cancer immunosurveillance

OncoImmunology

Mihaela Angelova¹  Jérôme Galon¹  Céline Mascaux² 

[1] INSERM, Laboratory of Integrative Cancer Immunology;Service De Pneumologie, Hôpitaux Universitaires De Strasbourg;

关键词: preinvasive;    immune response;    immunoprevention;    lung squamous cell carcinoma;    carcinogenesis;    immunotherapy;    immune contexture;    cancer prevention;    prophylactic;    microenvironment;   

DOI  :  10.1080/2162402X.2021.1912250

来源: DOAJ

【 摘 要 】

Early intervention and risk stratification solutions for lung cancer are limited by our understanding of how carcinogenesis transforms the pre-invasive epithelium and its microenvironment before the carcinoma stage. We describe the sequence of molecular and cellular changes leading to cancer formation and the co-evolution of the earliest immune response. We revealed that immune sensing, infiltration and activation of immune cells, immune escape, and microenvironment reorganization occur early in pre-cancer. These findings urge the need for broadening the scope of the established immunotherapy approaches toward prophylactic cancer treatment and preventive intervention. Leveraging the immune contexture and the mechanisms of immune modulation for individuals at risk of developing cancer and further to the general population will allow for early detection, chemoprevention, and risk stratification in the near future.

【 授权许可】

Unknown