Taste-Driven Responsiveness to Fat and Sweet Stimuli in Mouse Models of Bariatric Surgery

Biomedicines

Séverine Ledoux¹  Cédric Le May²  Pascaline Delaby³  Cindy Le Bourgot⁴  Arnaud Bernard⁵  Aurélie Dastugue⁵  Philippe Besnard⁵ 

[1] Explorations Fonctionnelles, Hôpital Louis Mourier (APHP), 92700 Colombe, France;Institut du Thorax, CNRS, INSERM, University of Nantes, 44000 Nantes, France;Lesieur, 92600 Asnières/Seine, France;Tereos, 77230 Moussy-le-Vieux, France;UMR 1231, INSERM/University of Bourgogne-Franche-Comté/AgroSup Dijon, 21000 Dijon, France;

关键词: obesity;    bariatric surgery;    gustation;    brief-access licking tests;    fat and sugar;   

DOI  :  10.3390/biomedicines10040741

来源: DOAJ

【 摘 要 】

A preferential consumption of healthier foods, low in fat and sugar, is often reported after bariatric surgery, suggesting a switch of taste-guided food choices. To further explore this hypothesis in well-standardized conditions, analysis of licking behavior in response to oily and sweet solutions has been realized in rats that have undergone a Roux-en-Y bypass (RYGB). Unfortunately, these studies have produced conflicting data mainly due to methodological differences. Paradoxically, whereas the vertical sleeve gastrectomy (VSG) becomes the most commonly performed bariatric surgery worldwide and is easier to perform and standardize in small animals, its putative impacts on the orosensory perception of energy-dense nutrients remains unknown. Using brief-access licking tests in VSG or RYGB mice, we found that (i) VSG induces a significant reduction in the fat mass in diet-induced obese (DIO) mice, (ii) VSG partially corrects the licking responses to lipid and sucrose stimuli which are degraded in sham-operated DIO mice, (iii) VSG improves the willingness to lick oily and sucrose solutions in DIO mice and (iv) RYGB leads to close outcomes. Altogether, these data strongly suggest that VSG, as RYGB, can counteract the deleterious effect of obesity on the orosensory perception of energy-dense nutrients in mice.

【 授权许可】

Unknown