Sleep Timing May Predict Congestive Heart Failure: A Community‐Based Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Fan Gao¹  Jiamei Li²  Xuting Jin²  Xiaochuang Wang²  Gang Wang²  Ruohan Li²  Ya Gao²  Bin Yan²  Jingjing Zhang²  Jiajia Ren² 

[1] Department of Clinical Research Centre The First Affiliated Hospital of Xi'an Jiaotong University Shaanxi China;Department of Critical Care Medicine The Second Affiliated Hospital of Xi'an Jiaotong University Shaanxi China;

关键词: bedtime;    congestive heart failure;    sleep timing;    wake‐up time;   

DOI  :  10.1161/JAHA.120.018385

来源: DOAJ

【 摘 要 】

Background Previous studies have suggested that sleep timing is associated with cardiovascular risk factors. However, there is no evidence on the relationship between sleep timing and congestive heart failure (CHF). We aimed to examine this relationship in this study. Methods and Results We recruited 4765 participants (2207 men; mean age, 63.6±11.0 years) from the SHHS (Sleep Heart Health Study) database in this multicenter prospective cohort study. Follow‐up was conducted until the first CHF diagnosis between baseline and the final censoring date. Sleep timing (bedtimes and wake‐up times on weekdays and weekends) was based on a self‐reported questionnaire. Cox proportional hazard models were constructed to investigate the association between sleep timing and CHF. During the mean follow‐up period of 11 years, 519 cases of CHF (10.9%) were reported. The multivariable Cox proportional hazards models revealed that participants with weekday bedtimes >12:00 am (hazard ratio [HR], 1.56; 95% CI, 1.15–2.11; P=0.004) and from 11:01 pm to 12:00 am (HR, 1.25; 95% CI, 1.00–1.56; P=0.047) had an increased risk of CHF compared with those with bedtimes from 10:01 pm to 11:00 pm. After stratified analysis, the association was intensified in participants with a self‐reported sleep duration of 6 to 8 hours. Furthermore, wake‐up times >8:00 am on weekdays (HR, 1.53; 95% CI, 1.07–2.17; P=0.018) were associated with a higher risk of incident CHF than wake‐up times ≤6:00 am. Conclusions Delayed bedtimes (>11:00 pm) and wake‐up times (>8:00 am) on weekdays were associated with an increased risk of CHF.

【 授权许可】

Unknown