期刊论文详细信息
Evolutionary Applications
Gene drive strategies of pest control in agricultural systems: Challenges and opportunities
Sarina Macfadyen1  Mathieu Legros1  Luke G. Barrett1  Keith R. Hayes2  Andy Sheppard3  John M. Marshall4 
[1] CSIRO Agriculture and Food Canberra ACT Australia;CSIRO Data 61 Hobart Tas. Australia;CSIRO Health and Biosecurity Canberra ACT Australia;Divisions of Biostatistics and Epidemiology – School of Public Health University of California Berkeley CA USA;
关键词: agriculture;    gene drive;    genetic control;    pest control;    resistance;    risk analysis;   
DOI  :  10.1111/eva.13285
来源: DOAJ
【 摘 要 】

Abstract Recent advances in gene‐editing technologies have opened new avenues for genetic pest control strategies, in particular around the use of gene drives to suppress or modify pest populations. Significant uncertainty, however, surrounds the applicability of these strategies to novel target species, their efficacy in natural populations and their eventual safety and acceptability as control methods. In this article, we identify issues associated with the potential use of gene drives in agricultural systems, to control pests and diseases that impose a significant cost to agriculture around the world. We first review the need for innovative approaches and provide an overview of the most relevant biological and ecological traits of agricultural pests that could impact the outcome of gene drive approaches. We then describe the specific challenges associated with using gene drives in agricultural systems, as well as the opportunities that these environments may offer, focusing in particular on the advantages of high‐threshold gene drives. Overall, we aim to provide a comprehensive view of the potential opportunities and the remaining uncertainties around the use of gene drives in agricultural systems.

【 授权许可】

Unknown   

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