The role m6A RNA methylation is CNS development and glioma pathogenesis

Molecular Brain

Ping Zhang¹  Liwen Li²  Liang Xia²  Caixing Sun²  Fan Wu³  Shiyan Wu³  Fang Zhou³  Ting Pan³ 

[1] Department of Gynecological Oncology, Cancer Hospital of University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences;Department of Neurosurgery, Cancer Hospital of University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences;School of the Second Clinical Medical College, Zhejiang Chinese Medical University;

关键词: Glioma;    GBM;    m6A methylation;    METTL3;    WTAP;    ALKBH5;   

DOI  :  10.1186/s13041-021-00831-5

来源: DOAJ

【 摘 要 】

Abstract Epigenetic abnormalities play a crucial role in many tumors, including glioma. RNA methylation occurs as an epigenetic modification similar to DNA methylation and histone modification. m6A methylation is the most common and most intensively studied RNA methylation, which can be found throughout the RNA life cycle and exert biological functions by affecting RNA metabolism. The m6A modification is primarily associated with three types of protease, which are encoded by the writer, eraser and reader genes, respectively. It has been shown that the m6A methylation has close connections with the occurrence and development of many tumors, including glioma. In this study, the concept and the research progress of m6A methylation are reviewed, especially the role of m6A methylation in glioma. Moreover, we will discuss how glioma is paving the way to the development of new therapeutic options based on the inhibition of m6A deposition.

【 授权许可】

Unknown