A Modified 2 Tier Chemotherapy Response Score (CRS) and Other Histopathologic Features for Predicting Outcomes of Patients with Advanced Extrauterine High-Grade Serous Carcinoma after Neoadjuvant Chemotherapy

Cancers

BryanM. Fellman¹  BarrettC. Lawson²  Jinsong Liu²  Yanping Zhong²  Xiaoran Li²  Anais Malpica²  NicoleD. Fleming³  ShannonN. Westin³  RobertL. Coleman³  AnilK. Sood³  Sanghoon Lee⁴ 

[1] Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;

关键词: extrauterine;    high-grade serous carcinoma;    neoadjuvant chemotherapy;    chemotherapy response score;    pathology features;    survival;   

DOI  :  10.3390/cancers13040704

来源: DOAJ

【 摘 要 】

Background: The impact of chemotherapy response score (CRS) on prognosis has varied among studies. We addressed the prognostic significance of CRS and the prognostic value of previously undescribed histologic features using a cohort of 245 patients. Methods: Retrospective study in patients with advanced extrauterine high-grade serous carcinomas treated with neoadjuvant chemotherapy followed by interval tumor reductive surgery from 1990 to 2018 in our hospital. Gynecologic pathologists assessed tumor CRS and other histologic features. Clinical information was collected, and multivariate analyses were conducted. Results: A modified 2 tier CRS (CRS 1/2 versus CRS 3) was significantly associated, independent of scoring site (omental versus adnexal), with overall survival (OS) (omentum, p= 0.018; adnexa, p = 0.042; entire cohort, p = 0.002) and progression-free survival (PFS) (p = 0.021, p = 0.035, and p = 0.001, respectively). On multivariate survival analysis, 2 tier CRS, oncocytic change, inflammation, and desmoplasia were significant for OS (p = 0.034, p = 0.020, p = 0.007, and p = 0.010, respectively). Likewise, 2 tier CRS, inflammation, and desmoplasia were significant for PFS (p= 0.012, p = 0.003, p= 0.011, respectively). Conclusions: The modified 2 tier CRS was significantly associated with survival, independent of scoring site. Additional histologic features including oncocytic change, inflammation, and desmoplasia can also predict patient outcomes.

【 授权许可】

Unknown