Glycosylation efficiencies on different solid supports using a hydrogenolysis-labile linker

Beilstein Journal of Organic Chemistry

Peter H. Seeberger¹  Mayeul Collot¹  Markus Weishaupt¹  Steffen Eller¹ 

[1] Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14776 Potsdam, Germany;

关键词: glycosylation;    hydrogenolysis;    linkers;    oligosaccharides;    resins;    solid-phase synthesis;   

DOI  :  10.3762/bjoc.9.13

来源: DOAJ

【 摘 要 】

Automated oligosaccharide assembly requires suitable linkers to connect the first monosaccharide to a solid support. A new hydrogenolysis-labile linker that is stable under both acidic and basic conditions was designed, synthesized and coupled to different resins. Glycosylation and cleavage efficiencies on these functionalized solid supports were investigated, and restrictions for the choice of solid support for oligosaccharide synthesis were found.

【 授权许可】

Unknown